Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients.

INTRODUCTION: The aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases. METHODS: We used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient. RESULTS: A total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR: 1.38; 95% CI: 1.21-1.57), being in stage III or IV (OR: 1.32; 95% CI: 1.08-1.62), not having comorbidities (OR: 5.21; 95% CI: 4.59-5.91), presenting with symptoms at diagnosis (OR: 1.53; 95% CI: 1.29-1.81), and having ALK translocation (OR: 7.61; 95% CI: 1.25-46.32) and HER2 mutation (OR: 5.71; 95% CI: 1.34-24.33), compared with subjects ≥50 years. Among subjects <35 years old (n=61), our study observed a higher proportion of women (59.0% vs. 26.6%; p<0.001), never smokers (45.8% vs. 10.3%; p<0.001), no comorbidities (21.3% vs. 74.0%; p<0.001); ALK translocation (33.3% vs. 4.4%; p<0.001) and ROS1 mutation (14.3% vs. 2.3%; p=0.01), compared with subjects ≥35 years. CONCLUSIONS: Lung cancer displays differences by age at diagnosis which may have important implications for its clinical management.

Adenomatoid paratesticular tumor: report of 5 new cases and literature review.

OBJECTIVE: To report 5 cases of adenomatoid tumor of the epididymis that have been diagnosed in the last 11 years at our hospital. We performed a bibliographic review with discussion of diagnosis, differential diagnosis and treatment of this rare type of lesion. METHOD: We have performed a retrospective analysis of epididymal adenomatoid tumors diagnosed during the last 11 years in our hospital, from January 2001 to June 2012. RESULTS: The average age of the series was 44 years. The predominant reason for consultation was long duration painless scrotal mass, with palpable nodule, usually dependent of the epididymis. 60% of the patients have been studied with abdominal ultrasound, which showed a nodular paratesticular lesion, with an echogenicity compatible with solid tissue. Tumor markers associated with testicular tumors (alpha-fetoprotein (AFP)), beta-human chorionic gonadotropin (b-HCG) and lactate dehydrogenase (LDH) were analyzed in 60% of the cases, being normal in all patients. 3 lumpectomies, 1 epididymectomy and 1 radical orchiectomy have been performed. CONCLUSIONS: The discovery of a solid epididymal mass is uncommon in clinical practice. Physical examination and imaging tests should confirm the paratesticular origin of the lesion, being then trans-scrotal epididymectomy the treatment of choice. If diagnosis is uncertain, inguinal approach and intraoperative biopsy are mandatory.

Tumor adenomatoide de epidídimo: Aportación de 5 casos y revisión de la literatura / Adenomatoid paratesticular tumor: report of 5 new cases and literature review

OBJETIVO: Presentar los 5 casos de tumor adenomatoide epididimario, diagnosticados en los últimos 11 años en nuestro centro. Revisión bibliográfica y discusión del diagnóstico diferencial y tratamiento de este tipo de lesiones poco frecuentes en la práctica clínica. MÉTODO: Se realiza un análisis retrospectivo de los casos de tumor adenomatoide epididimario diagnosticados durante los últimos 11 años en nuestro hospital, desde enero de 2001 a febrero de 2012. RESULTADOS: La edad media de la serie fue de 44 años. El motivo de consulta predominante fue masa escrotal no dolorosa de larga evolución, con nódulo palpable, generalmente dependiente del epidídimo. En el 60% de los casos se realizó ecografía abdominal, en la cual se observó lesión paratesticular nodular de ecogenicidad compatible con tejido sólido. En el 60 % de los casos se analizaron los marcadores tumorales relacionados con tumores testiculares: alfafetoproteína (AFP), beta-gonadotropina coriónica humana (b-HCG) y lactato deshidrogenasa (LDH), que resultaron normales. Se realizaron 3 tumorectomías, 1 epididimectomía y 1 orquiectomía radical. CONCLUSIONES: El hallazgo de una masa sólida epididimaria es infrecuente en la práctica clínica. La exploración física y pruebas de imagen deben confirmar el origen paratesticular de la lesión, siendo entonces la epididimectomía transescrotal el tratamiento de elección. Ante duda diagnóstica, el abordaje quirúrgico por vía inguinal con biopsia intraoperatoria de la tumoración es mandatorio

OBJECTIVE: To report 5 cases of adenomatoid tumor of the epididymis that have been diagnosed in the last 11 years at our hospital. We performed a bibliographic review with discussion of diagnosis, differential diagnosis and treatment of this rare type of lesion. METHOD: We have performed a retrospective analysis of epididymal adenomatoid tumors diagnosed during the last 11 years in our hospital, from January 2001 to June 2012. RESULTS: The average age of the series was 44 years. The predominant reason for consultation was long duration painless scrotal mass, with palpable nodule, usually dependent of the epididymis. 60% of the patients have been studied with abdominal ultrasound, which showed a nodular paratesticular lesion, with an echogenicity compatible with solid tissue. Tumor markers associated with testicular tumors (alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (b-HCG) and lactate dehydrogenase (LDH)) were analyzed in 60% of the cases, being normal in all patients. 3 lumpectomies, 1 epididymectomy and 1 radical orchiectomy have been performed. CONCLUSIONS : The discovery of a solid epididymal mass is uncommon in clinical practice. Physical examination and imaging tests should confirm the paratesticular origin of the lesion, being then trans---scrotal epididymectomy the treatment of choice. If diagnosis is uncertain, inguinal approach and intraoperative biopsy are mandatory

Bladder endometriosis: report of 7 new cases and review of the literature.

OBJECTIVE: To describe our experience with bladder endometriosis at the Department of Urology of Complejo Hospitalario Universitario de Santiago de Compostela. METHODS: We performed a retrospective analysis of the cases of bladder endometriosis diagnosed during the last 11 years in our hospital, from January 2000 to December 2011. RESULTS: A total of 7 women, with a mean age of 32-year-old have been diagnosed by biopsy of bladder endometriosis. The most common symptoms were dysuria, suprapubic pain, urinary urgency and hematuria. All patients have undergone surgery (5 transurethral resection, 2 partial cystectomy), 6 of them were also treated with post-operative LHRH analogues. CONCLUSIONS: Endometriosis is a common disease in young women, but the involvement of the urinary tract is unusual. There are multiple therapeutic options; despite this there exists a high probability of recurrence.

Endometriosis vesical: aportación de 7 nuevos casos y revisión de la literatura / Bladder endometriosis: report of 7 new cases and review of the literature

OBJETIVO: Describir nuestra experiencia en el Departamento de Urología del Complejo Hospitalario Universitario de Santiago de Compostela en endometriosis vesical. MÉTODOS: Se realiza un análisis retrospectivo de los casos de endometriosis de vejiga diagnosticados durante los últimos 11 años en nuestro hospital, desde enero de 2000 a diciembre de 2011. RESULTADOS: Un total de 7 mujeres, con un promedio de 32 años de edad, ha sido diagnosticadas por biopsia de endometriosis vesical. Los síntomas más frecuentes han sido disuria, dolor suprapúbico, urgencia urinaria y hematuria. Todas ellas han sido tratadas con cirugía (5 con resección transuretral, 2 con cistectomía parcial), en 6 de ellas se asociaron análogos de LHRH en el post-operatorio. CONCLUSIONES: La endometriosis es una enfermedad común en mujeres jóvenes, pero la afectación de las vías urinarias es inhabitual. Existen múltiples posibilidades terapéuticas, pero a pesar de ello es alta la probabilidad de recurrencia

OBJECTIVE: To describe our experience with bladder endometriosis at the Department of Urology of Complejo Hospitalario Universitario de Santiago de Compostela. METHODS: We performed a retrospective analysis of the cases of bladder endometriosis diagnosed during the last 11 years in our hospital, from January 2000 to December 2011. RESULTS: A total of 7 women, with a mean age of 32-year-old have been diagnosed by biopsy of bladder endometriosis. The most common symptoms were dysuria, suprapubic pain, urinary urgency and hematuria. All patients have undergone surgery (5 transurethral resection, 2 partial cystectomy), 6 of them were also treated with post-operative LHRH analogues. CONCLUSIONS: Endometriosis is a common disease in young women, but the involvement of the urinary tract is unusual. There are multiple therapeutic options; despite this there exists a high probability of recurrence